University of Washington

Nanopore Physics Lab

From left to right: Dr. Brain Ross, Henry Brinkerhoff, Kyle Langford, Jenny Mae Samson, Dr. Ian Derrington, Graham Nayler, Andrew Laszlo, Elizabeth Manrao, Ian Nova, Dr. Jens Gundlach, and Siripunt Vimolchalao


One of our newest publications was featured on the cover of the April 2012 issue of Nature Biotechnology;

This paper is a significant step forward towards the development of a nanopore sequencing device. It introduces a system where a DNA polymerase is used to slowly pass DNA through the MspA nanopore. The resulting signal may be used to resolve single nucleotide movement through the pore.

You can read more about these recent advances to nanopore sequencing in Science Magazine, and UW Today.

Recent Publications

Molecular Dynamics Study of MspA Arginine-Mutants Predicts Slow DNA Translocations and Ion Current Blockades Indicative of DNA Sequence.
S. Bhattacharya, I. Derrington, M. Pavlenok, M. Niederweis, J. Gundlach, and Aleksei Aksimentiev
ACS Nano 6(8) pp 6960-6968, July 2, 2012

Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase
Elizabeth A Manrao, Ian M Derrington, Andrew H Laszlo, Kyle W Langford, Matthew K Hopper, Nathaniel Gillgren, Mikhail Pavlenok, Michael Niederweis & Jens H Gundlach
Nature Biotechnology (Cover), April 2012

MspA Nanopores from Subunit Dimers.
M. Pavlenok, I. Derrington, J. Gundlach, M Niederweis
PLoS ONE 7(6) e38726, October 4, 2011

Nucleotide Discrimination with DNA Immobilized in the MspA Nanopore
Elizabeth A. Manrao, Ian M. Derrington, Mikhail Pavlenok, Michael Niederweis, Jens H. Gundlach
PLoS ONE 6(10) e25723, October 2011

Address: B033 Physics-Astronomy Building University of Washington 3910 15th Ave. NE Seattle, WA 98195-1560
Update: March 23, 2012